Intelligence / Retatrutide

Retatrutide

Under Review
Triple Agonist (GLP-1/GIP/Glucagon)
Schedule
S4
Under Review
Enforcement
Monitoring
Medium Risk
Providers
2
Access: Emerging
Key Facts
Schedule 4 - Prescription Only
Triple GLP-1/GIP/Glucagon receptor agonist
Not yet TGA-approved
Phase 3 trials ongoing globally
Grey market supply emerging in Australia

Overview

Retatrutide is a novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. It is not yet TGA-approved and remains in Phase 3 clinical trials globally. Grey market supply has emerged in Australia.

Australian Scheduling

Schedule 4 (Prescription Only). Not yet TGA-approved or ARTG-listed. Under active regulatory monitoring. Grey market supply is under increasing scrutiny.

Access Pathway

Very limited legal prescription access through 2 identified providers. Most Australian supply is currently through grey market channels, which carries significant regulatory and quality risk.

Regulatory Notice

For informational purposes only. TGA scheduling may change without notice. All Schedule 4 peptides require a valid prescription from a registered Australian medical practitioner. This site does not sell, supply, or facilitate access to therapeutic goods. Data compiled from TGA SUSMP, public provider directories, and publicly available review platforms.

News & Updates20 items
Emerging risks of health optimisation: refractory nausea associated with peptide injections reported to contain retatrutide.
BMJ case reports7 Oct 2026
Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats
Behav Brain Res2 Oct 2026
Retatrutide trial: Triple action jab can cause weight loss of up to 25%, results suggest.
BMJ (Clinical research ed.)1 Oct 2026
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.
The New England journal of medicine29 Sept 2026
Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.
Lancet (London, England)29 Sept 2026
The Possible Hematological Cost of Metabolic Success: Do Incretin-Based Therapies Silently Trigger Anemia?
Medical sciences (Basel, Switzerland)17 Sept 2026
Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.
Rapid communications in mass spectrometry : RCM16 Sept 2026
Sustained weight loss exceeding 100 kg with sequential incretin-based therapy in Prader-Willi syndrome.
JCEM case reports16 Sept 2026
Obstructive sleep apnea, GLP-1 receptor agonist pharmacotherapy, and the oral microbiome: competing biological influences and implications for oral health monitoring.
Clinical oral investigations14 Sept 2026
TGA tests counterfeit retatrutide product following serious adverse event report
TGA13 Sept 2026
CARDIOVASCULAR EFFECTS OF INCRETIN RECEPTOR AGONISTS: BEYOND GLYCEMIC CONTROL.
Canadian journal of physiology and pharmacology10 Sept 2026
Advances in the management of obesity: non-pharmacological strategies, herbal formulations, current pharmacotherapy, emerging drugs, and future perspectives.
Frontiers in endocrinology7 Sept 2026
Retatrutide: how demand for a new weight-loss drug is feeding an industry of fakes
BBC News4 Sept 2026
From insulin resistance to incretin receptor agonism in the prevention of type 2 diabetes mellitus in obese individuals
Curr Med Res Opin3 Sept 2026
Pharmacological management of obesity: Current landscape and emerging therapies.
Indian journal of pharmacology2 Sept 2026
Recent Studies on the Effectiveness and Safety of Anti-Obesity Medications: A Scoping Review.
Diabetes, metabolic syndrome and obesity : targets and therapy2 Sept 2026
Composition and Labelling Accuracy of Products Sold as Retatrutide in Australia
Drug Alcohol Rev1 Sept 2026
Beyond Fat Loss: Addressing the Sarcopenia Challenge of Incretin-Based Therapies.
Diabetes & metabolism journal1 Sept 2026
Incretin-based therapies in diabetic kidney disease: toward integrated cardio-kidney-metabolic disease modification.
Kidney research and clinical practice1 Sept 2026
People risk the grey market for retatrutide, the newest weight-loss drug
The Guardian31 Aug 2026

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